王雪峰

肿瘤免疫

分子免疫

感染免疫

教育经历

2013/08-2014/08，美国匹兹堡大学，免疫学，访问学者

2003/9 - 2006/12，苏州大学，免疫学，博士

1996/9 - 1999/7，扬州大学，生物化学与分子生物学，硕士，

工作经历

2007/11 - 至今，苏州大学，基础医学与生物科学学院，副教授

2002/4 - 2007/10，苏州大学，生命科学学院，讲师

1.    Feng C, Cao LJ, Song HF, Xu P, Chen H, Xu JC, Zhu XY, Zhang XG, Wang XF* (corresponding author). Expression of PD-L1 on CD4+CD25+Foxp3+ Regulatory T Cells of Patients with Chronic HBV Infection and Its Correlation with Clinical Parameters. Viral Immunol. 2015 Oct;28(8):418-24. doi: 10.1089/vim.2015.0062. Epub 2015 Aug 12. PubMed PMID: 26266813. (IF=1.446)

2.    Wang X, Zhao X, Feng C, Weinstein A, Xia R, Wen W, Lv Q, Zuo S, Tang P, Yang X, Chen X, Wang H, Zang S, Stollings L, Denning TL, Jiang J, Fan J, Zhang G, Zhang X, Zhu Y, Storkus W, Lu B. IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. Cancer Cell. 2015 Sep 14;28(3):296-306. doi: 10.1016/j.ccell.2015.07.014. Epub 2015 Aug 27. PubMed  PMID: 26321222; PubMed Central PMCID: PMC4573903. (IF=23.523)

3.    Gao X#, Wang X# (co-first author), Yang Q, Zhao X, Wen W, Li G, Lu J, Qin W, Qi Y, Xie F, Jiang J, Wu C, Zhang X, Chen X, Turnquist H, Zhu Y, Lu B. Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and  NK cells. J Immunol. 2015 Jan 1;194(1):438-45. doi: 10.4049/J Immunol.1401344. Epub 2014 Nov 26. PubMed PMID: 25429071; PubMed Central PMCID: PMC4272901. (IF=4.922)

4.    Xu P, Chen YJ, Chen H, Zhu XY, Song HF, Cao LJ, Wang XF* (corresponding author). The expression of programmed death-1 in circulating CD4+ and CD8+ T cells during hepatitis B virus  infection progression and its correlation with clinical baseline characteristics. Gut Liver. 2014 Mar;8(2):186-95. doi: 10.5009/gnl.2014.8.2.186. Epub 2013 Dec 24. PubMed PMID: 24672661; PubMed Central PMCID: PMC3964270. (IF=1.810)

5.    Wang X, Zhu G, Huang Z, Cao L, Chen Y, Wang Q, Zhang X. Application of monoclonal antibodies in a sandwich enzyme-linked immunosorbent assay for identification and detection of soluble human B and T lymphocyte attenuator. Hybridoma (Larchmt). 2012 Dec;31(6):417-23. doi: 10.1089/hyb.2012.0052. PubMed PMID: 23244320. (IF=0.337)

6.    Wang XF, Chen YJ, Wang Q, Ge Y, Dai Q, Yang KF, Fang-Xie, Zhou YH, Hu YM, Mao  YX, Zhang XG. Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells. Tissue Antigens. 2007 Feb;69(2):145-53. PubMed PMID: 17257317. (IF=2.137)

7.    WANG Xuefeng, HONG Fashui, SHEN Songdong, SU Guoxing, PAN Xingfa. Effect of Cerium on Activity of α-Amylase from Porcine Pancreas. Journal of Rare Earths. 2002(5):553-556. (IF=1.261)

8.    Chen Y, Hu Z, Wang Q, Ge Y, Bai L, Wang X, Zhang X. Generation and characterization of four novel monoclonal antibodies against human programmed death-1 molecule. Hybridoma (Larchmt). 2010 Apr;29(2):153-60. doi: 10.1089/hyb.2009.0091. PubMed PMID: 20443708.

9.    Duan Y, Liu J, Ma L, Li N, Liu H, Wang J, Zheng L, Liu C, Wang X, Zhao X, Yan  J, Wang S, Wang H, Zhang X, Hong F. Toxicological characteristics of nanoparticulateanatase titanium dioxide in mice. Biomaterials. 2010 Feb;31(5):894-9. doi: 10.1016/j.biomaterials.2009.10.003. Epub 2009 Oct 25. PubMed PMID: 19857890.

10.  Cheng Z, Zhou S, Wang X, Xie F, Wu H, Liu G, Wang Q, Chen Y, Hu Y, Lu B, Zhang X. Characterization and application of two novel monoclonal antibodies against human CXCR4: cell proliferation and migration regulation for glioma cell line in  vitro by CXCR4/SDF-1alpha signal. Hybridoma (Larchmt). 2009 Feb;28(1):33-41. doi: 10.1089/hyb.2008.0069. PubMed PMID: 19239368.

11.  Wang Q, Chen Y, Xie F, Ge Y, Wang X, Zhang X. A novel agonist anti-human OX40L monoclonal antibody that stimulates T cell proliferation and enhances cytokine secretion. Hybridoma (Larchmt). 2009 Aug;28(4):269-76. doi: 10.1089/hyb.2009.0013. PubMed PMID: 19663699.

12.  Zhou YH, Chen YJ, Ma ZY, Xu L, Wang Q, Zhang GB, Xie F, Ge Y, Wang XF, Zhang XG. 4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells. Tissue Antigens. 2007 Aug;70(2):96-104. PubMed PMID: 17610414.

13.  Liu C, Hong FS, Wu K, Ma HB, Zhang XG, Hong CJ, Wu C, Gao FQ, Yang F, Zheng L, Wang XF, Liu T, Xie YN, Xu JH, Li ZR. Effect of Nd3+ ion on carboxylation activity of ribulose-1,5-bisphosphate carboxylase/oxygenase of spinach. BiochemBiophys Res Commun. 2006 Mar 31;342(1):36-43. Epub 2006 Feb 2. PubMed PMID: 16469293.

14.  Wang Q, Chen Y, Xie F, Ge Y, Chen L, Wu H, Qu Q, Wang X, Zhang X. Development  of a sandwich ELISA for evaluating soluble OX40L (CD252) in human sera of different ages or with Graves' disease. Cytokine. 2006 Oct;36(1-2):23-8. Epub 2006 Dec 12. PubMed PMID: 17166734.

15.  Hong FS, Wang XF, Su GX, Pan XF, Shen SD. [Mechanism of heavy metal ions on RNase activity from bovine pancreas].GuangPuXue Yu GuangPu Fen Xi. 2002 Aug;22(4):651-4. Chinese. PubMed PMID: 12938389.

16.  宋华峰，齐嫄, 黄子逸，吴妹英，胥萍，王雪峰*（通讯作者）, 张学光. 一株鼠抗人HVEM单克隆抗体的研制及初步鉴定. 现代免疫学, 2014; 34(1): 14-18.

17.  黄子逸, 朱耿超, 王雪峰*（通讯作者），张学光. 人HVEM-Fc融合蛋白的制备及其生物学特性. 现代免疫学, 2013; 33(1): 19-22.

18.  曹丽娟, 宋华峰, 朱耿超, 黄子逸, 王雪峰*（通讯作者）, 张学光. 人膜型LIGHT对Mo-DC成熟和T细胞激活的调节作用. 现代免疫学, 2013; 33(2): 89-93.

19.  朱耿超, 黄子逸, 曹丽娟, 陈永井, 王雪峰*（通讯作者）, 张学光. 人BTLA-Fc融合蛋白的制备及其生物学活性的研究. 现代免疫学, 2011; 31(5): 363-367.

20.  王雪峰,陈永井,王勤等.一株鼠抗人BTLA功能性单克隆抗体的研制及其生物学特性鉴定[J].现代免疫学,2007,27(1):18-22.DOI:10.3969/j.issn.1001-2478.2007.01.004.

1.    国家自然科学基金项目，31570889、IL-36/IL-36R信号介导CD8+T细胞抗肿瘤免疫应答的机制、2016/01-2019/12、70万元、在研、主持。

2.    横向项目：特异性鼠抗人ICOSL单克隆抗体的研制、2015/4-2017/3、资助经费10万元、在研、主持。

1. 中国医学生物化学与分子生物学分会青年委员

江苏省“青蓝工程”优秀青年骨干教师